Comparison of overall quality of life and function after two limb-sparing procedures in adolescent patients with periarticular osteosarcoma of the knee
NI Yan
YANG Jing
JIANG Da-li
Abstract：Objective To investigate the effects of tumour prosthesis replacement and tumour segment resection and inactivation on quality of life and lower limb function in patients with periarticular osteosarcoma (OS) of the knee. Methods Ninety-two patients with periprosthetic knee OS who were surgically treated between July 2022 and July 2023 in our hospital were selected. The patients were divided into the tumour prosthesis replacement group (n=52) and the tumour segment resection and inactivation and reimplantation group (n=40) according to the surgical approach. Musculoskeletal tumor society (MSTS) and Toronto Extremity Salvage Score (TESS) were used to evaluate lower limb function preoperatively,3 months after surgery,and 6 months after surgery,respectively. The 36-Item Short Form Survey (SF-36) and the Quality of Life Questionnaire-core 30 (QLQ-C30) were used to evaluate the quality of life of cancer patients. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the negative mood of the patients. Results The MSTS scores of patients in the tumor prosthesis replacement group at 3 months[(18.93±3.87) vs. (20.62±3.23)]and 6 months[(22.31±3.57) vs. (24.11±2.91)]after surgery were lower than those in the tumor segment resection and inactivation replantation group(P<0.05). The TESS scores of patients in the tumor prosthesis replacement group at 3 months[(67.57±16.03) vs. (73.87±13.34)]and 6 months[(75.06±17.87) vs. (82.82±17.36)]after surgery were lower than those in the tumor segment resection and inactivation replantation group (P<0.05). At 3 months and 6 months after surgery,the scores of physiological,physiological and social functions in SF-36 in the tumor prosthesis replacement group were (40.14±17.85,43.52±15.92),(44.17±22.18,47.25±26.24) and (62.85±14.54,65.24±20.59),respectively,which were lower than those in the tumor resection and inactivation and replantation group[(59.34±18.77,64.58±17.40),(58.75±20.26,63.75±23.73) and (69.31±16.02,74.47±16.24)](P<0.05). The QLQ-C30 scores of the patients after surgery in the tumor prosthesis replacement group were lower than those in the tumor segment resection inactivation and replantation group at 3 months[(70.35±17.55) vs. (77.69±16.47)]and 6 months[(77.82±14.15) vs. (84.34±13.51)](P<0.05). The SAS scores of patients in the tumor prosthesis replacement group at 3 months[(54.05±6.38) vs. (49.36±8.06)]and 6 months[(51.24±6.27) vs. (41.57±6.78)]after surgery were higher than those in the tumor segment resection inactivation and replantation group (P<0.05). The SAS scores of patients in the tumor prosthesis replacement group at 3 months[(53.24±7.81) vs. (48.87±6.14)]and 6 months[(45.57±6.24) vs. (37.32±5.89)]after surgery were higher than those in the tumor segment resection inactivation and replantation group (P<0.05). Conclusions Tumour segment resection inactivation and replantation is superior to tumour prosthesis replacement in improving lower limb function and quality of life in adolescent patients with periprosthetic knee OS.
Keywords：OsteosarcomaArthroplastyreplacementkneeChemotherapy
Publication Date：2025-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 47-52 )