Clinicopathological characteristics and prognosis of primary bone lymphomas
GUO Guo-ning
CHEN Jing-chang
PENG Ling
WANG Chang-song
Abstract：Objective To study the clinicopathological features,diagnosis,differential diagnosis and prognosis of bone primary lymphoma.Methods The clinical manifestations,pathologic-morphological features,immunophenotype,treatment and prognosis of 10 patients with PBLs were retrospectively analyzed.Results PBLs mostly occurred in middle-aged men.Most involved single bone(70%,7/10),and a few involved multiple bones(30%,3/10).The patients had no specific clinical manifestation,and the imaging manifestations included osteolytic lesions and pathological fractures.Morphologically,the tumor cells were diffusely distributed.The cell volume was large,the size was consistent,the nucleus was round,and pathological nuclear division was visible.Tumor cells expressed B lymphocyte markers but not T lymphocyte markers.Conclusions PBLs is a rare lymphomas originating from bone,and the histological type is mainly DLBCL.Accurate diagnosis is based on the pathological and immunohistochemistry methods,with good prognosis by combination therapy.
Keywords：LymphomaBone neoplasmsPathologysurgicalImmunophenotypingPrognosisPrimary bone lymphomas
Publication Date：2024-05-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 331-335 )