Extracorporeally irradiated autografts for the treatment of limb osteosarcoma
GU Zhi-yuan
WANG Xin
YAO Wei-tao
TIAN Zhi-chao
LIU Zhi-yong
CAI Qi-qing
Abstract：Objective To investigate the short-term clinical results of extracorporeal irradiated autograft for the reconstruction after limb osteosarcoma resection in children.Methods From Jun to Dec, 2016, we used extracorporeal irradiated autograft to reconstruct the defect after osteosarcoma resection in limbs of children (n=6, 3 males and 3 females).The mean age was 12.7 years (range:11-15 years).All were ranked Enneking stage IIB.All tumors located around the knee, including 4 in the femur and 2 in the tibia.The mean length of the autograft was24.8 cm (range:18-35 cm).After en-bloc resection of the tumor, the autograft underwent bolus irradiation of 60 Gy in isocenter with the mean of 30 min (range:25-40 min).Then reconstruction with the locked compress plate was applied.Results All cases were followed up with a mean of 12.8 months (range:16-18 months).No recurrence was observed.Lung metastasis was found in 2 cases, 1 died 6 months after operation and the other one was alive (12 months after operation).In 5 patients alive, bone union was achieved in 4 patients with the mean follow-up of8.5 months (range:6-10 months).The mean MSTS scores was 24.6 (range:22-29).Complications occurred in3 patients, including 1 fixation breakage and 2 knee stiffness.But all got satisfied results after the second operation.Conclusions Extracorporeal irradiated autograft reconstruction is feasible with good clinical results and high security.
Keywords：X-raysOsteosarcomaBone transplation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )