3D-printed prosthesis combined with β-TCP porous bioceramics on the reconstruction of segmental bone defect in lower extremities after osteosarcoma resection
LU Ya-jie
LONG Zuo-yao
LI Ming-hui
CHEN Guo-jing
LI Jing
FU Jun
LU Jian-xi
WANG Zhen
Abstract：Objective To explore the feasibility of the reconstruction of segmental defect after resection of osteosarcoma in lower extremities with 3D-printed prosthesis combined withβ-TCP porous bioceramics and evaluate its short-term clinical efficacy.Methods From January 2017 to November 2018, 6 patients with lower limb osteosarcoma who met the inclusion criteria were recruited.The surgical strategy and the 3D-printed prosthesis were designed based on the preoperative CT data.After tumor resection, the 3D-printed prosthesis combined withβ-TCP porous bioceramic granules were installed and fixed.All patients were followed up and evaluated regularly after operation.The functional status was assessed by the Musculoskeletal Tumor Society (MSTS) score.Oncology results and complications were recorded in detail.Results All operations were successfully performed.The mean follow-up period was 9.5 months.Postoperative imaging results showed that all the implants were stable without complications such as peripheral infection, aseptic loosening or fracture.At the last follow-up, all patients survived without tumour recurrence or metastasis.The 3D-printed prosthesis composite achieved substantial bone integration at follow-up more than 9 months after the operation.The average MSTS score was 85.33％ (60.00％-96.67％).Conclusions The3D printed prosthesis combined withβ-TCP porous bioceramics can be used to reconstruct the bone defect after the resection of osteosarcoma in the lower extremities, and the clinical efficacy was satisfactory in the short-term followup.It provides a new option for the reconstruction of large bone defect after tumor resection.
Keywords：3D-printedβ-tricalcium phosphateReconstructionOsteosarcomaBone defect
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 21-26 )