The analysis of five patients for pelvic radiation-induced sarcoma
WANG Chong-ren
HUA Ying-qi
SUN Wei
SHEN Jia-kang
SUN Meng-xiong
FU Ze-ze
ZHOU Cheng-hao
CAI Zheng-dong
Abstract：Objective To explore clinical features, treatment and prognosis of pelvic radiation-induced sarcoma. Methods Five cases of pelvic radiation-induced sarcoma ( RIS ) underwent tumor excision, internal fixation and chemotherapy from 2014 to 2017. Results All patients were female. Primary tumors included 2 endometrial carcinomas, 2 cervical carcinomas and 1 malignant teratoma. The period from radiotherapy to RIS was ( 13.6 ± 4.7 ) years. Lung metastases occurred in 4 cases. Three cases received surgery and postoperative chemotherapy, one case received surgery alone and one case received chemotherapy. Histological classification: 4 cases were of osteosarcoma and 1 was of leiomyosarcoma. After the follow-up for 3 to 11 months, all 5 cases died. Conclusions Pelvic radiation-induced sarcoma is highly malignant with rich blood supply. It has dismal prognosis, and high rate to metastasize. Anticipated morbidity of RIS is increasing. Palliative surgery and chemotherapy are suggested.
Keywords：PelvisNeoplasmsOsteosarcomaChemoradiotherapyTherapy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 14-19 )