Effects of calcitriol on bone mechanical structure in diabetic rats
ZHENG Ya
ZHANG Feng
CAO Jian-ye
DONG Li-wei
GAO Wen-shuang
ZHANG Jing
Abstract：Objective To investigate the effects of calcitriol on bone mechanical structure in diabetic rats. Methods Diabetic rat model was established from streptozotoein. The diabetic rats were randomly divided into the diabetic group ( DM ) and the vitamin D treated group ( VD ), while the healthy SD rats were used as the normal control group ( NC ). The rats in the VD group were continuously fed with 1,25-dihydroxyvitaminD3for 6 weeks and 9 weeks. Right femurs were harvested for biomechanical analysis, while the left for bone histomorphometry data. Results Compared with the NC group in the same period, biomechanical properties were significantly lower in the DM group, as well as the static parameters ( percent trabecular area, trabecular thickness, trabecular number ) ( Ρ < 0.05 ), while the trabecular separation was significantly increased ( Ρ < 0.05 ). With administration for 6 weeks, the rats in the VD group showed a significant increase in maximum load ( 132.47 ± 11.00 ), break load ( 115.37 ± 7.64 ), trabecular number ( 3.562 ± 0.374 ) and percent trabecular area ( 26.531 ± 3.388 ) %, while trabecular thickness was significantly decreased compared with the DM group ( Ρ < 0.05 ). After treated for 9 weeks, the VD group also displayed significant changes in biomechanical properties ( elastic load and rigid coefficient ) and static parameters compared to the DM group ( Ρ < 0.05 ). Conclusions Calcitriol can improve the degradation of the microstructure and increase the femur stability of the mechanical structure in diabetic osteoporosis rats, playing a therapeutic role in the osteoporosis.
Keywords：Diabetes mellitusRatsOsteoporosisCalcitriolBiomechanics
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 818-822 )