Effectiveness and safety of topical tranexamic acid in total hip arthroplasty: a meta-analysis
SHANG Yi-mei
LIU Ming-ting
XU Chuang
WANG Jian-ming
REN Qiang
LI Jian
DU Chang-ling
Abstract：Objective To explore the effectiveness and safety of topical tranexamic acid in total hip arthroplasty. Methods The criteria for inclusion and exclusion were formulated. Following databases were searched, PubMed, EBSCO, The Cochrane Library, WanFang database and China National Knowledge Infrastructure ( CNKI ), from Jan. 1999 to Oct. 2016. A Meta-analysis for screening and quality estimation were conducted with Review Manager 5.2. Results Eleven eligible studies involving 1072 participants ( 569 topical TXA and 503 control ) were included in this meta-analysis. Topical tranexamic acid significantly reduced the total blood loss [ WMD =-419.51, 95％ CI ( -507.64, -331.38 ), P < 0.00001 ], and the proportion of patients requiring blood transfusion [ RR = 0.26, 95％ CI ( 0.18, 0.36 ), P < 0.00001 ], without increased thromboembolic complications [ RR = 1.50, 95％ CI ( 0.42, 5.40 ), P = 0.54 ). Conclusions Topical tranexamic acid is effective in reducing total blood volume and transfusion rate of total hip arthroplasty; in the meantime, it is safe and will not increase the incidence of thromboembolic complications.
Keywords：Tranexamic acidAdministrationtopicalArthroplastyreplacementhipMeta-analysisValidation studies
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 686-691 )