The clinical effects of sulfasalzine combined with mental intervention therapy in the treatment of ankylosing spondylitis and its influence on patients' psychological status
DOU Qiang
LIU Jia-chun
GAO Jie
LI Zhi-lin
YANG Cheng-wei
LAN Xu
Abstract：Objective To observe the clinical effects of sulfasalzine combined with mental intervention therapy in the treatment of ankylosing spondylitis ( AS ) and its influence on patients' anxiety and depression. Methods A total of 63 patients with AS were randomly divided into observation group and control group. The control group [ 30 patients, male: 12, female: 18, the average age: ( 26.0 ± 9.2 ) y ] was given sulfasalzine only, and the observation group [ 33 patients, male: 16, female: 17, the average age: ( 28.5 ± 8.1 ) y ] were given sulfasalzine combined with mental intervention therapy. The assessment of Spondylo Arthritis international society ( ASAS ) 20, bath ankylosing spondylitis disease activity index ( BASDAI ), tumor necrosis factor-ɑ ( TNF-ɑ ), interleukin-6 ( IL-6 ) and IL-23 levels, function of the liver and kidney, self-reported anxiety scale ( SAS ) and self-reported depression scale ( SDS ) were recorded before and after the treatment. Results At 4 weeks after the treatment, BASDAI scores of both groups were positively decreased compared with that before the treatment, and the differences were statistically significant ( P < 0.05 ). The difference value of BASDAI score of observation group was significant compared with that of control group. The difference values of BASDAI scores of both groups were respectively 4.66 ± 0.50 and 1.88 ± 0.91 before and after the treatment ( P < 0.05 ). The levels of TNF-ɑ, IL-6 and IL-23 of both groups were positively decreased compared with that before the treatment, and the differences were statistically significant ( P < 0.05 ). The differences of SAS and SDS in observation group before and after the treatment were significant compared with that in control group ( P < 0.01 ). The difference values of SAS in both groups were respectively 15.73 ± 0.93 and 2.23 ± 1.04, and the difference values of SDS in both groups were respectively 16.21 ± 1.86 and 2.15 ± 1.10. The differences of liver and kidney function in both groups were significant before and after the treatment. Conclusions The sulfasalzine combined with mental intervention therapy can reduce TNF-ɑ, IL-6 and IL-23 levels of AS patients and ease the degree of anxiety and depression.
Keywords：SpondylitisankylosingSulfasalazineAnxietyDepressionMental intervention therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 297-300 )