Clinical research on the making of surgical margin in limb soft tissue sarcomas by simultaneous integrated boost intensity modulated radiation therapy
ZHOU Yang
LIANG Zhen
LI Rui
BAI Jing-ping
Abstract：Objective To investigate the clinical effects of simultaneous integrated boost intensity modulated radiation therapy ( SIB-IMRT ) for making surgical margin in limb soft tissue sarcomas ( STS ). Methods A total of 41 patients with locally advanced limb STS were treated by SIB-IMRT before the operation. The prescription dose included planning target volume ( PTV ) DT 42.0 - 45.0 Gy ( 15 f, 3 weeks ) and simultaneous integrated boost-gross tumor volumes ( SIB-GTVs ) DT 45.0 - 52.5 Gy ( 15 f, 3 weeks ), 5 - 7 fields. The operation was performed at 3 - 6 weeks after SIB-IMRT. The limb circumference and tumor size were measured before and after SIB-IMRT, as well as the 2-year relapse-free survival. Results The limb circumferences were ( 53.17 ± 17.81 ) cm and ( 50.62 ± 18.14 ) cm before and after SIB-IMRT. The circumference was shrunk by ( 2.42 ± 1.75 ) cm on average, and the differences were statistically significant ( P < 0.05 ). The SIB-IMRT response rate was 80.49% ( 33 / 41 ), with volume shrinkage in 33 cases, complete remission ( CR ) in 0 case, partial remission ( PR ) in 18 cases and stable disease ( SD ) in 23 cases after SIB-IMRT. The follow-up lasted for 7 - 55 months. The wound complication rate was 2.4%, and the 2-year relapse-free survival was 87.80%. There were 4 cases of pulmonary metastases, 5 cases of recurrence and 2 cases of both. Conclusions The short-term effects of the SIB-IMRT technology for making surgical margin in locally advanced limb STS are definite, with good tolerance.
Keywords：RadiotherapySarcomaSurgical proceduresoperativeSIB-IMRT
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 124-127 )