Clinical observation of dynamical changes of thrombelastography in perioperative period of multiple myeloma ;bone disease
YU Yao
DU Xin-ru
CHEN Wen-ming
LUO Hui
XU Zi-yu
Abstract：Objective Using thrombelastography ( TEG ) to monitor the perioperative blood coagulation state of patients with myeloma bone disease ( MBD ), and to explore the relationship between the blood coagulation state of patients with MBD and clinical classiifcation, tumor staging and application of heparin. Methods A total of 21 MBD patients received surgical treatment in our hospital from August 2013 to March 2015 and were registered as the research group. Twenty-two healthy adults receiving health examination were registered as the control group. TEG and traditional coagulation test were examined before the operation in all cases of 2 groups, and the MBD group also received TEG test at the 1st, 3rd, 5th and 7th day after the operation respectively. Results ( 1 ) There were no significant differences between MBD group and the control group in TEG and traditional coagulation test results ( P>0.05 ), the P-values of each parameter were R 0.334, K 0.066, Angle 0.265, MA 0.095, CI 0.315, PT 0.462, APTT 0.310, Fbg 0.051, TT 0.821 and PLT 0.071. ( 2 ) In the dynamic changes of perioperative blood coagulation of MBD patients, the results of TEG were not obviously different between pre and postoperation ( P>0.05 ), the P-values of each parameter were R 0.361, K 0.675, Angle 0.487, MA 0.279, EPL 0.398, CI 0.775, LY30 0.398. ( 3 ) There were no statistical signiifcant differences between the TEG test using heparin or not ( P>0.05 ) in MBD patients, the P-values of each parameter were R 0.518, K 0.831, Angle 0.676, MA 0.304, EPL 0.307, CI 0.971, LY30 0.307. ( 4 ) There was no statistical signiifcance in the results of TEG and traditional coagulation test for different MBD classiifcation ( P>0.05 ), the P-values of each parameter were R 0.342, K 0.531, Angle 0.574, MA 0.856, EPL 0.737, CI 0.505, LY30 0.747, PT 0.393, APTT 0.790, Fbg 0.966, TT 0.115, PLT 0.460. ( 5 ) There was also no statistical signiifcance between the results of TEG of traditional coagulation test for different MBD staging ( P>0.05 ), the P-values of each parameter were R 0.293, K 0.198, Angle 0.178, MA 0.515, EPL 0.748, CI 0.125, LY30 0.748, PT 0.464, APTT 0.649, Fbg 0.649, TT 0.646, PLT 0.515. Conclusions The blood coagulation status in patients with MBD is complex. There are still many problems unsolved in the perioperative management of patients with MBD. We could use TEG test to assess the blood coagulation status in patients with MBD accurately.
Keywords：Multiple myelomaThrombelastographyThrombosisHeparin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 700-705 )