Management of Madelung’s disease：report of 11 cases and literature review
YU Yao
DU Xin-ru
LUO Hui
XU Zi-yu
Abstract：Objective To investigate the etiology, pathogenesis, imaging characteristics, laboratory examination, pathology, diagnosis, and treatment of Madelung’s disease.Methods Clinical data of eleven cases of Madelung’s disease were analyzed retrospectively and relevant literature was reviewed.Results Nine patients were presented with “fatty neck”, 2 patients were presented with “fatty neck” and “fatty limbs”. Two patients had a history of alcohol abuse for more than 20 years. B-ultrasound and MRI examinations showed massive subcutaneous deposits of adipose tissue around the neck and limbs. Blood pressure, blood glucose and liver function returned to normal after comprehensive medical treatment. Hyperplasia of adipose tissue was resected under general anesthesia. Nine samples were confirmed as no capsule hyperplasia of adipose tissue by histopathology after the operation. Patients were followed up for 6 - 36 months ( mean: 15 months ). Three patient experienced recurrence 36 months after the operation. Conclusions Madelung’s disease is a rare disease and the recognized etiology is the long-term excessive drinking. A comprehensive management plan is required to treat this disease. Surgical resection of local hyperplasic adipose tissue helps alleviate the symptoms of oppression and improve the appearance of neck and limbs.
Keywords：Lipomatosismultiple symmetricalNutritional and metabolic diseasesMagnetic resonance imagingPathological conditionssigns and symptomsDiagnosisdifferential
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 616-622 )