Calcium phosphate cement versus polymethylmethacrylate cement in the percutaneous kyphoplasty of osteoporotic vertebral fractures

JIA Xiao-lin; TAN Zu-jian; YANG Fu-bin; Thomas Stoffels

doi:10.3969/j.issn.2095-252X.2016.05.015

Abstract：Objective To compare the clinical and radiographic outcomes after percutaneous kyphoplasty ( PKP ) using calcium phosphate cement ( CPC ) versus polymethylmethacrylate ( PMMA ) for osteoporotic vertebral fractures.Methods The study was conducted on 48 patients from July 2011 to May 2013. Twenty-three patients ( 9 males and 14 females ) with an average age of 69.59 ( range: 61 - 82 years ) received CPC. Twenty-ifve patients ( 11 males and 14 females ) with an average age of 71.23 ( range: 67 - 89 years ) were treated with PMMA-cement. Pain ( visual analog scale, VAS ), duration of analgesics, operation satisfaction rate, radiomorphologic measurements and complications were assessed at baseline and after 3, 6, 12, and 24 months.Results There were no statistically signiifcant differences between the CPC and PMMA group regarding VAS-scores, duration of analgesics, operation satisfaction rate, degree of vertebral compression or local kyphosis at any time point (P > 0.05 ). Furthermore, there were no significant differences in the occurrence of adjacent vertebral fractures and cement leakage between both groups during the follow-up (P > 0.05 ). However, the compression rates of the vertebrae in the CPC group were ( 17.22 ± 14.19 ) % after the operation immediately, ( 23.26 ± 10.08 ) % 3 months postoperatively, and ( 23.39 ± 11.23 ) %at the ifnal follow-up. There was a signiifcant correction loss of vertebral height at the 3-month follow-up and from then on (P < 0.05 ).Conclusions CPC is as effective and safe as conventional PMMA-cement with regard to pain reduction and improvement of mobility after the kyphoplasty of patients with painful osteoporotic vertebral fractures.