Kimura disease：1 case report and 81 cases literature review

HU Tan; WU Ji; WU Di; ZHENG Chao; HUANG Rong-rong

doi:10.3969/j.issn.2095-252X.2015.09.007

Abstract：Objective To explore the epidemiological and pathological characteristics, clinical manifestations, diagnosis and differential diagnosis, clinical treatment and prognosis of Kimura disease by summarizing clinical data of 81 patients with Kimura disease.Methods One case admitted in our department in 2014 was reported. Chinese biological and medical literature databases such as Wanfang, China National Knowledge Infrastructure ( CNKI ) and Vip from January 2000 to December 2014 were searched. Key words were Kimura, Kimura’s disease and eosinophilic lymphoid granuloma.Results There were 82 cases ( 63 males and 19 females ) with complete clinical data ( including 1 case in our hospital ). The male female ratio was 3.3:1. The mean age was 39 years, and mean disease course 5.79 years. 78.05% of cases presented with the head and neck subcutaneous mass, and 41.46% were accompanied by regional lymphadenopathy. Simple lymph node enlargement occurred in 21.95% of cases, salivary gland involvement in 21.95%, local symptoms of mass in 40.24%, and related complications in 35.37%. Peripheral blood eosinophilia and elevated serum immunoglobulin E ( IgE ) were found in 85.37% and 42.68% of cases respectively. 28.05% and 18.29% of cases were treated with surgical operation and steroid hormones respectively and 45.12% with combined therapy.Conclusions Kimura disease is a rare chronic inlfammatory disorder of unknown etiology, and usually presents as a subcutaneous mass in the head and neck region or the major salivary glands of young to middle-aged Asian men. It is often associated with regional lymphadenopathy. Elevated serum IgE and peripheral blood eosinophilia are also common. Though surgical resection, regional or systemic steroid therapy and local radiation have good effects, recurrence may occur.