Report of 9 cases of malignant transformation in extremity benign bone tumors
XIAO He
DING Yi
NIU Xiao-hui
Abstract：Objective To report cases of malignant transformation of bone tumors which were conventionally thought to be rare so as to prove the existence of malignant transformation in benign bone tumors, providing reference for clinical management of bone tumors.Methods Records of all in-patient since the establishment of our center were searched and rare cases of malignant transformation in benign bone tumors were selected.Results There were 7446 cases of non-malignant bone tumors including osteochondroma, enchondroma, neurofibromatosis, and giant cell tumors which were 4 common malignant tumor types. Nine cases of rare malignant transformation in extremity bone tumors were found out from a total of 4662 cases to date. Malignant transformation rate was 0.193% ( 9 / 4662 ). Pre-existing benign tumors of 9 cases included fibrous dysplasia, benign fibrous tumor, inflammatory lesion of the bone, synovial chondromatosis, chondromyxoma, aneurysmal bone cyst and chondromyxoid ifbroma, etc. Clinical, radiographic and pathological characteristics were analyzed. Previously proposed hypotheses were also reviewed in an effort to speculate the possible reasons of malignant transformation of these cases.Conclusions The possibility of malignant transformation exists in ifbrous dysplasia, benign ifbrous tumor, inlfammatory lesion of the bone, synovial chondromatosis, chondromyxoma, aneurysmal bone cyst and chondromyxoid ifbroma, which should be noted in the management of bone tumors.
Keywords：Bone neoplasmsExtremitiesNeoplasmssecond primaryChondromatosissynovialBone cysts
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 669-675 )