Detection of serum IGF-1, iPTH, BALP, OC levels in renal osteodystrophy patients and their correlations with bone mineral density
LIAO Wu-qiong
LI Dian-geng
LI Qing-gang
CHEN Xiang-mei
Abstract：Objective To study the serum insulin-like growth factor 1 ( IGF-1 ), intact parathyroid hormone ( iPTH ), bone alkaline phosphatase ( BALP ), osteocalcin ( OC ) levels in renal osteodystrophy patients and their correlations with bone mineral density.Methods Eighty cases of chronic kidney disease patients in our hospital from from 2013 April - 2014 May were enrolled in the observation group. Eighty cases of the healthy were enrolled in the control group. Then serum IGF-1, iPTH, BALP, OC levels and bone density of L3, L4 vertebrae, trochanter, Ward’s region in the two groups were detected.Results ( 1 ) Serum index: IGF-1 level of observation group ( 145.2±17.8 ) μg / L was lower than control group ( 245.2±31.5 ) μg / L; iPTH level of observation group ( 234.8±27.3 ) ng / L; BALP level of observation group ( 94.9±11.5 ) U / L, OC level of observation group ( 13.9±1.6 ) μg / L was higher than control group ( 58.8±6. 9 ) ng / L, ( 35.6±4.5 ) U / L, ( 6.7±0.8 ) μg / L individually( P<0.05 ). ( 2 ) Bone density: bone density of L3 vertebrae ( 0.817±0.104 ) g / cm2, L4 vertebrae ( 0.742±0.094 ) g / cm2, trochanter ( 0.744±0.108 ) g / cm2, Ward’s region ( 0.762±0.091 ) g / cm2, greater trochanter ( 0.804±0.089 ) g / cm2 of observation group were lower than those of control group ( 1.056±0.186 ) g / cm2, ( 1.008±0.13 ) g / cm2, ( 0.907±0.12 ) g / cm2, ( 0.899±0.104 ) g / cm2, ( 0.948±0.118 ) g / cm2 (P<0.05 ); ( 3 ) Serum IGF-1 level was positively correlated with bone density (P<0.05 ). Serum iPTH, BALP, OC levels was negatively correlated with bone density (P<0.05 ).Conclusions Bone density of renal osteodystrophy patients decreases signiifcantly and is closely correlated with serum IGF-1, iPTH, BALP, OC levels. High level of IGF-1 and low levels of iPTH, BALP, OC demonstrate high bone density.
Keywords：OsteocalcinRenal osteodystrophyInsulin-like growth factor-IAlkaline phosphataseBone density
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 485-487 )