Expressions of cellular prion protein and the correlation analysis of prognosis in osteosarcoma of Enneking III
BAI Yun-peng
DONG Yang
ZHANG Zhi-chang
YANG Qing-cheng
XU Ze-quan
YAN Hong-liang
Abstract：Objective To investigate the expressions of cellular prion protein ( PrPc ) in Enneking III osteosarcoma and analyze its correlation with the metastasis and prognosis.Methods Immunohistochemistry streptavidin-perosidase ( SP ) method was used to detect the expressions of PrPc in 15 patients with osteosarcoma of Enneking III who had pulmonary metastases at the ifrst visit and in the corresponding adjacent tissues. By contrast, the same detection was performed on 33 patients with non-metastatic osteosarcoma at the first visit who were adopted during the same period. The expressions of PrPc between the 2 groups were compared. The clinical data of the 48 patients with osteosarcoma were retrospectively reviewed, including the sex, age, tumor location, tumor size, pathologic fractures, survival time and so on. Their admission time ranged from January 2006 to December 2009. The Kaplan-Meier method was used to measure the overall survival rate. A log-rank univariate analysis was used to determine the prognostic factors related to the survival rate. The Cox multivariate analysis model was used to identify the independent prognostic factors. The relationship between the expressions of PrPc and different clinical features and the survival rate in the patients with osteosarcoma were explored.Results The expressions of PrPc were noticed in the osteosarcoma tissues but not in the adjacent tissues. The expression level in the patients with Enneking III osteosarcoma was signiifcantly higher than that in the control group (P=0.006 ). The Kaplan-Meier survival analysis and Log-rank test showed that the PrPc expression level (P=0.010 ) and the Enneking staging (P=0.025 ) were related to the prognosis. The Cox regression analysis showed that the PrPc expression level and the Enneking staging were the prognostic factors of osteosarcoma patients.Conclusions The PrPc expressions are signiifcantly higher in the patients with metastatic osteosarcoma of Enneking III than in the non-metastatic group. The higher PrPc expressions indicate a poor prognosis. The PrPc expressions may be associated with the poor prognosis of osteosarcoma.
Keywords：OsteosarcomaGene expressionPrognosisPrPc
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 516-520 )