Expressions and clinical signiifcance of fascin-1 in giant cell tumors of bone
LU Qiang
WU Chun-yun
WANG Bao-cang
LIU Lan-ze
LI Yong
WANG Hui
YAN Ming
Abstract：Objective Fascin-1 is the 55 kilodalton ( kDa ) F-actin-binding cytoskeletal protein, which takes part in the formation of cellular membrane protrusions and cell migration. Fascin-1 is upregulated in several types of carcinomas. To investigate the relationship between the fascin-1 expressions in giant cell tumors of bone and the related clinical parameters.Methods A total of 65 patients with giant cell tumors of bone were adopted by the second Hospital of Tangshan, including 30 males and 35 females. Their average age was 35 years old ( range: 9-58 years ). The average follow-up period was 51.5 months ( range: 12.5-80.0 months ). Immunochemistry with digital image analysis was used to determine the fascin-1 protein expressions in histologic sections from the 65 patients. The fascin-1 expressions of 65 tissue samples were detected by immunochemistry. The fascin-1 expressions with the clinicopathologic features of giant cell tumors of bone were assessed.Results The fascin-1 expressions were positive in 40 of the 65 patients with giant cell tumors of bone, and the positive rate was 66.7%. Cytoplasm was the main location. A correlation study was performed between the fascin-1 expressions and various indexes relfecting the tumor prognosis. The results showed positive expressions were noticed in 20 of 36 patients with benign giant cell tumors of bone ( 55.6% ) and in 19 out of 27 patients with invasive tumors ( 70.3% ). The fascin-1 expressions were positive in 2 patients with malignant and metastatic tumors. Patients with good prognosis were observed. The positive expressions were found in 10 out of 16 patients with recurrence, accounting for 62.5%. The data above demonstrated that the fascin-1 expressions were signiifcantly correlated with the classiifcation and prognosis of tumors (P<0.05 ), but not with the gender, age, tumor location or tumor size (P>0.05 ).Conclusions Fascin-1 is upregulated in giant cell tumors of bone, which may play an important role in their recurrence and malignant transformation. So fascin-1 could be a new target in the treatment of giant cell tumors of bone.
Keywords：Giant cell tumor of boneBone neoplasmsImmunohistochemistryFascin-1 protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 507-510 )