Combined usage of atorvastatin and alendronate in the treatment of middle-aged and elderly patients with osteoporosis
ZHAO Zhi-kun
QU Feng
LIU Run-mei
LI Liang
ZHAI Hong-xia
YIN Ya-xin
ZHANG Jin-jin
XIA Yun-feng
Abstract：Objective To study the effects of atorvastatin and alendronate used together in the treatment of osteoporosis, and their effectiveness in reducing the risk of complications.Methods 129 patients were divided into the alendronate group (n=65 ) who had alendronate plus caltrate D through the mouth and the alendronate and atorvastatin group (n=64 ) who had alendronate + atorvastatin + caltrate D through the month. 12 months later, the total effective rate was compared between the 2 groups based on the lumbar pain scores. The bone density changes were observed, and the occurrence of new cases with increased carotid artery intima-media thickness was analyzed after the treatment of osteoporosis.Results After 12 months of treatment, the differences in the total effective rate based on the lumbar pain scores were not statistically signiifcant between the drug combination group and the single alendronate group. The annual gradient of bone density values in the drug combination group was ( 11.26±2.58 ) %, which was greater than ( 10.07±2.75 ) % in the single alendronate group (P<0.05 ). There were 4 new cases with increased carotid artery intima-media thickness in the drug combination group after the treatment, and while there were 14 new cases in the single alendronate group ( P<0.05 ).Conclusions The efifcacy of combined usage of alendronate and atorvastatin is better than the single usage of alendronate in the treatment of osteoporosis, and the risk of the complication of atherosclerosis can be effectively reduced.
Keywords：Drug therapycombinationOsteoporosisMiddle agedAgedAtorvastatinAlendronate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 54-57 )