Research progress on the occurence and development of osteoporosis mediated by gut microbiota through the immune-endocrine-nervous system
YANG Gang
CAO Xinyuan
LI Guangqi
JIANG Jun
LI Tianyi
WU Wenming
Abstract：Osteoporosis is a chronic metabolic bone disease mainly related to the imbalance of osteoblast and osteoclast metabolism in the body.Gut microbiota(GM)are symbiotic bacteria that reside in the intestine and have important functions such as maintaining the intestinal mucosal barrier function,regulating host metabolism,and maintaining immune homeostasis of the body.In recent years,there are sufficient evidences indicating that GM can regulate bone mass,mainly through the interaction between GM,GM metabolites and the immune,endocrine,and nervous systems of the body.This article conducts a literature review including three aspects of GM introduction,the correlation between GM and the onset of osteoporosis,and the mediation of the occurrence and development of osteoporosis by GM through the immune-endocrine-nervous system,with the aim of providing references and strategies for the further prevention and treatment of osteoporosis.
Keywords：Gastrointestinal microbiomeImmune systemEndocrine systemNervous systemOsteoporosisBone metabolism
Publication Date：2025-06-15
Online Publishing Date：2025-12-19(First online date of this platform, not the publication date of the document)
Pages：7( 206-212 )