Clinical study of enoxaparin sodium combined with pneumatic compression pump for preventing venous thromboembolism in elderly surgical patients with orthopedic trauma

MIAO Jianhua; ZHANG Zhiqiang; WANG Yongtang

doi:10.3969/j.issn.1674-666X.2025.02.007

Abstract：Objective To investigate the clinical efficacy and safety of enoxaparin sodium combined with pneumatic compression pump in preventing venous thromboembolism(VTE)in elderly surgical patients with orthopedic trauma.Methods A retrospective analysis of the clinical data of 96 elderly patients with limb or pelvic fractures who underwent surgical treatment from April 2024 to January 2025 at Zhengzhou Central Hospital was conducted.According to different VTE prevention measures after the surgery,the patients were divided into the observation group(54 cases)and the control group(42 cases).The observation group was given enoxaparin sodium combined with pneumatic compression pump,while the control group was given enoxaparin sodium alone.The coagulation function indexes,hemodynamic parameters,distal collateral circulation,VTE incidence and drug-related adverse events were compared between the two groups.Results The activated partial thromboplastin time and prothrombin time of the observation group were longer than those of the control group,and the levels of fibrinogen and D-dimer were lower than those of the control group(P<0.05).In the observation group,whole-blood viscosity and plasma viscosity were lower,and hematocrit was higher than those in the control group,but the inter-group difference was not statistically significant(P>0.05).The peak systolic blood flow velocity was higher,and the resistance index was lower in the observation group than those in the control group(P<0.05).The incidence of VTE was lower in the observation group than that in the control group(P<0.05).The incidence of drug-related adverse events in the two groups had no statistical difference(P>0.05).Conclusion Compared with enoxaparin sodium alone,combination with pneumatic compression pump after the surgery is a safe and effective prevention measure of VTE with further improvement of the coagulation function indexes and promotion of distal collateral circulation for elderly patients with orthopedic trauma.