Short-term efficacy of screw-hook fixation and bone morphogenetic protein bone grafting in the repair of lumbar isthmic spondylolysis in the youth
HUANG Xianhua
LIANG Zhongbiao
HE Yinghua
XIE Ningling
YU Dong
TU Qiang
Abstract：Objective To study the effect of bone morphogenetic protein (BMP)-2 combined with autogenous iliac bone graft on the rate of bone fusion at 12 months after the repair of lumbar isthmic spondylolysis for young patients who performed screw-hook internal fixation. Methods A retrospective analysis was performed on 89 young patients with lumbar isthmic spondylolysis who underwent screw-hook internal fixation in General Hospital of Southern Theater Command from January 2022 to January 2023. Forty-two patients with BMP-2 autologous bone grafting were selected as the observation group,and 47 patients with autologous bone grafting were selected as the control group. The therapeutic effect indicators and the rate of isthmic bone fusion at 12 months after surgery were compared between the two groups. Results The operation was successful in both groups,and there was no significant differences in operation time,intraoperative blood loss and postoperative drainage volume (P>0.05). Visual analogue scale (VAS) score,Oswestry disability index (ODI) and Japanese Orthopaedic Association (JOA) score of the two groups were significantly improved compared with those before surgery (P<0.05),and there were no statistical differences of lumbar lordosis angle in two groups between preoperation and postoperation (P>0.05). The bone fusion rate of the observation group and control group at 12 months postoperatively was 47.62％ (20/42) and 17.02％ (8/47) respectively,the difference showed statistically significant (P<0.05). Conclusion BMP-2 combined with autogenous iliac bone transplantation could significantly improve the bone fusion rate at 12 months after screw-hook internal fixation for young patients with lumbar isthmic spondylolysis.
Keywords：Lumbar vertebraeIsthmic spondylolysisYoung adultScrew-hook fixationBone morphogenetic protein 2Bone transplantationTransplantationautologousSpinal fusion
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 252-257 )