The role of exosome-mediated tissue engineering in bone repair
YOU Yonggang
CHEN Suli
WANG Xiaofeng
LI Zhanqing
Abstract：The treatment of bone nonunion and bone defects due to severe trauma and bone tumors is a challenge for orthopedic surgeons.Cell-based bone tissue engineering techniques provide an effective method for bone defect repair.With a deeper understanding of the role of stem cells in tissue regeneration,researchers have identified stem cell-derived exosomes as one of the therapeutic mechanisms that guide bone regeneration.Exosomes are able to regulate bone regeneration and angiogenesis during bone formation by acting as intercellular communication through paracrine signaling.This article describes the biological origin,composition and function of exosomes,and discusses the regulatory role of exosomes in bone repair from the perspective of molecular biology.In addition,we summarize the research results of exosomes in bone tissue engineering to promote the repair of bone defects.These findings will help researchers to better understanding the mechanism of exosome action,and to provide novel therapeutic strategy to bone defect repair.
Keywords：ExosomesTissue engineeringFractureununitedBone defectBone repairMesenchymal stem cellsMacrophagesStents
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 137-144 )