Advancements in the research of MSC in bone repair within the context of piezoelectric medicine
LI Guojian
WU Changhua
ZHENG Guan
Abstract：The bioelectric signal plays a crucial role in mediating the regulation of mesenchymal stem cells(MSC)differentiation and is involved in the process of bone repair.Piezoelectric materials have been applied to bone tissue engineering due to their good biocompatibility and the ability to simulate electrical signals in vivo.In recent years,there have been numerous successful reports of piezoelectric materials promoting bone repair process.However,the specific effects of electrical signal on MSC differentiation regulation remained unclear.Therefore,this paper overviews the latest research progress on electrical signal regulation of MSC osteogenic,chondrogenic,and adipogenic differentiation,as well as the application of different piezoelectric materials in bone tissue engineering.It also summarized the prospects for future development of piezoelectric medicine in bone repair.
Keywords：Electric signalPiezoelectric materialsBiocompatibility materialsMesenchymal stem cellsBone repairMultidirectional differentiationTissue engineering
Publication Date：2024-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 60-68 )