The relationship between perioperative serum PCT, BMP2 and postoperative hip functional recovery for patients with hip replacement

YE Woqiu; FENG Yixin

doi:10.3969/j.issn.1674-666X.2015.05.003

Abstract：Objective To investigate the relationship between perioperative serum procalcitonin (PCT),bone morphogenetic protein 2 (BMP2) and postoperative recovery of hip function for patients with hip replacement.Methods A total of 148 patients with femoral neck fractures who underwent hip replacement from January 2013 to October 2014 in Puning People's Hospital,were randomly selected as the observation group,and 30 healthy who underwent physical examination during the same period were selected as the control group.The serum levels of PCT and BMP2 were detected by enzyme-linked immunosorbent assay (ELISA) before the operation and 1,3,5,7,14 days after the operation.Recovery of hip function was evaluated by Harris hip score at 1,3,6 months postoperatively.Pearson correlation analysis was applied to analyze the relationship between perioperative serum PCT,BMP2 levels and postoperative recovery of hip joint function.Results The levels of serum PCT and BMP2 in the observation group were higher than those in the control group at the different time-points (P <0.05).In observation group,preoperative serum levels of PCT and BMP2 were higher than those at 3,5,7 and 14 d postoperatively (P <0.05).Harris hip score after 6 months was as follows: 69 excellent,51 good,22 fair and 6 poor.The levels of serum PCT in the patients who evaluated as good and excellent hip function were lower,while levels of BMP2 were higher when compared with the patients with fair or poor hip function (P <0.05); Postoperative function of hip joint was negatively correlated with serum PCT levels,while was positively correlated with serum BMP2 levels (P <0.05).Conclusion For patients with hip replacement,serum PCT,BMP2 levels can be used as reference indexes to evaluate the recovery of hip function,which patients with high serum PCT and low serum BMP2 may show poor hip function recovery.