The application of small animal imaging technology in the study of osteoarthritis animal model
LU Xiaodong
CHEN Wenlie
LIN Ruhui
LI Zuanfang
XU Yaye
Abstract：Imaging diagnostic methods of osteoarthritis (OA) mainly include X-ray films,CT,MRI and ultrasound,etc.,which have their own characteristics in terms of the specificity,sensitivity and the utilization.Compared with the above traditional imaging examination means,high-resolution small animal imaging technology such as Micro-CT and nuclear magnetic imaging developed in recent years is showing obvious advantages in image resolution,microscopic structure display,as well as quantitative analysis,and playing important role in the study of OA animal models.In this paper,the establishment of OA animal model and the characteristics of various imaging techniques were introduced,the roles of bony structure imaging and cartilage imaging of Micro-CT in OA animal model were reviewed,the application values of small animal nuclear magnetic imaging in OA animal model were discussed from aspects of cartilage imaging sequences selection,cartilage thickness measurement,cartilage composition analysis and other tissue lesions analysis.At the same time,future prospects of small animal imaging technology in OA animal model were expected.
Keywords：OsteoarthritisModelsanimalMicro-CTSmall animal nuclear magnetic imagingImage processingcomputer-assistedDiagnostic imagingCartilagearticular
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 236-242 )