Preliminary experimental study on osteogenesis biological effects of the Ti nanorod in rabbit models
LIN Xi
RUAN Zheng
HE Peng
YAO Zilong
ZHANG Yu
YIN Qingshui
Abstract：Objective To analyze the osseointegration at Ti nanorod material-bone interface, and to explore osteogenesis biological effect of nanostructure Ti rod. Methods Field emission scanning electron microscopy (FESEM) was employed to observe the morphology of Ti nanorod surface, energy dispersive spectroscopy (EDS) was applied to analyze the elements of the materials. Ti rod and Ti nanorod samples were randomly implanted into either side of tibia of New Zealand white rabbits. After 4, 12 weeks, Micro-CT and push-out test were applied to compare the differences of osseointegration at the material-tibia interface as well as damage load between 2 materials. Results FESEM showed 100 nm Ti surface were acquired and EDS showed nanorod were composed of Ti element only. No tissue necrosis or wound infection were observed and no loosening or pull-out of implants had happened. Four weeks and 12 weeks after implanting, Micro-CT showed osseointegration density in 100 nm Ti group was better than that in Ti group; damage load in 100 nm Ti group was also higher than the result in Ti group, there was statistical difference between two groups (P <0.05). Conclusion 100 nm Ti could improve the osseointegration density at the bone-material interface, and subsequently enhance bone healing rate in rabbit models.
Keywords：NanostructuresTitaniumBone healingBiomechanicsRabbits
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 105-110 )