Preparation and characterization of porous bioceramic scaffold based on additive manufacturing and gel-casting technology
LI Xiang
WANG Chengtao
Abstract： Objective To investigate a novel method for the preparation of porous bioceramic scaffold ofβ-tricalcium phosphate (TCP) based on additive manufacturing and gel-casting technology. Methods Internal porous structures of scaffold were designed by computer aided design (CAD) software, resin molds were produced by stereolithography, then the bioceramic slurry were cast into the molds, and were sintered to remove the resin mold after hardening. As a result, the porous bioceramic scaffolds of β-TCP were obtained. Characteristics of microcosmic pore structures, mechanical properties and cell compatibility of the scaffolds were examined subsequently. Results Porous structures of β-TCP scaffold were consistent with the original design, with the interval porosity of 45.1% ± 1.2%. and the pore size of 300 to 500 μm; The average compressive strength was 5.3 ± 0.8 MPa;The results of in vitro test showed that osteoblasts were well attached and spread on scaffold, which indicated that the porous scaffold had good biocompatibility. Conclusion A novel method based on additive manufacturing and gel-casting technology has been proposed to produce porous bioceramic scaffold, which can provide scaffolds with complex shape and controlled internal porous structures.
Keywords：CeramicsCalcium phosphatesBiocompatible materialsAdditive manufacturingGel-castingPorous scaffold
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 35-39 )