Analysis of surveillance results of drug resistance in tuberculosis in Hulin, 2014-2016

WANG Yan-fu; QI Zheng; YANG Wei; LIU Chang; LI Hong-hai; WANG Xin

doi:10.19568/j.cnki.23-1318.2019.02.016

Abstract：Objective To analyze the drug resistance of tuberculosis in Hulin from 2014 to 2016, provide the reference for the standardization of the use of anti-tuberculosis drugs.Methods A total of 270 strains were obtained, of which 1 failed and 9 kinds of drug sensitivity test were identified and tested against INH, S, EMB, RFP, OFX, CPM, PTO, PAS and KAM for 269 strains.Results A total of 267 strains (99.257％) of Hulin from 2014 to 2016 were mycobacterium tuberculosis complex strains, of which 191 were sensitive to the drug, 76 were resistant to the drug, the initial resistance rate was 27.54％, and retreatment resistance rate was 35.48％.The resistance rate of male was higher than that in female;living in cities and towns in the rate of resistance was higher than that in rural areas, the difference had no statistically significant (P>0.05).Poor working conditions had the higher rates, the difference was statistically significant (P<0.05).The first-line drug resistance rate was 27.51％, the first-line drug resistance rate of the newly treated patients was 26.89％, first-line drug resistance rate of the retreatment patients was 25.81％;second-line drug resistance rate was 4.09％.The second-line drug resistance rate of the newly treated patients was 3.36％.The drug resistance rate of second-line drugs in retreatment patients was 9.68％.The top five drug resistance sequences of 9 kinds of antituberculosis drugs were S (24.54％), INH (13.38％), RFP (8.18％), OFX (4.09％) and EMB (1.86％).Conclusion Middle-aged, elderly people, men and poor people are the focus groups.At the same time, attention should be paid to the standard use of anti-tuberculosis drugs to minimize the number of drug-resistant patients.