Design,Synthesis and Fungicidal Activity of Novel Arylamide Compounds
HAO Zesheng
LI Qipeng
WANG Jiaying
CHEN Jixiang
WANG Haili
ZHANG Xiaokang
ZHANG Xingang
JIANG Zhongping
HAN Jintao
Abstract：To develop novel fungicides suitable for the green control of fruit and vegetable diseases,12 nitro-containing aromatic amide compounds were designed and synthesized in this study.Their structures were confirmed by nuclear magnetic resonance(NMR),and their fungicidal activities against 4 common pathogenic fungi were evaluated.The results showed that most compounds exhibited moderate activity against Alternaria solani and Sclerotinia sclerotiorum,and weak activity against Botrytis cinerea and Rhizoctonia solani.Structure-activity relationship(SAR)analysis indicated that introduction of a 6-methyl group at the R2 position had a weak effect on antifungal activity,whereas addition of a nitro group at the R3 position generally led to decreased activity.Compounds I-2,I-8 and I-9 displayed favorable broad-spectrum activity,with inhibitory rates exceeding 50％ against four pathogens.Among them,compound I-9 showed the best activity,with inhibition rates of 75.75％ against S.sclerotiorum,which could be used as a lead compound for further optimization,providing solutions for the control of major diseases in fruits and vegetables and contributing to the green and sustainable development of the fruit and vegetable industry.
Keywords：Aromatic amidefungicidal activitymolecular designstructure-activity relationship
Publication Date：2026-04-30
Online Publishing Date：2026-08-28(First online date of this platform, not the publication date of the document)
Pages：6( 7-12 )