Preparation and its sustained-release properties of albumin-octreotide nanoparticles
LI Shengyuan
HUANG Yongpeng
TANG Hui
WANG Chunjiang
LI Xiulan
CHEN Bo
Abstract：Albumin nanoparticles were prepared by reverse solvent method.The effects of different crosslinking agents were compared by single factor experiment and Z-score comprehensive evaluation method.The effects of albumin mass concentration,the volumn ratio of alcohol to water,desolubilization temperature,solvent pH,crosslinking time and other process parameters on the performance of albumin nanoparticles were studied to determine the optimal process conditions.Albumin octreotide micropowder was prepared by impregnation adsorption-freeze-drying method.The drug loading capacity and in vitro dissolution performance of the micropowder were investigated.The results show that glutaraldehyde is the preferred crosslinking agent.When the albumin mass concentration is 10 g/L,the volume ratio of alcohol to water is 2∶1,the desolubilization temperature is 20℃,the solvent pH is 9,and the cross-linking time is 24 h,the preparation conditions of the albumin nanoparticles are the best.The average particle size of the prepared albumin nanoparticles is(100.6±2.5)nm,the polydispersion index is 0.13±0.01,and the storage stability was good.Albumin-octreotide micropowder maintains the original spherical morphology of albumin carrier,and the continuous release time is 2 160 min,showing good in vitro release performance.
Keywords：albuminoctreotidenanoparticlemicropowdersustained-release properties
Publication Date：2023-02-25
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：10( 39-48 )