Preparation of micro-nano drug particles by liquid phase precipitation with reinforced micromixing
CHEN Bo
HUANG Yongpeng
ZHONG Hui
JIAO Jianlan
ZOU Chuanpin
Abstract：Micro-nano particles of model drug pentoxyverine citrate were prepared by anti-solvent or reactive precipitation method.The micromixing of liquid phase precipitation was reinforced by micro-channel or high gravity reactor simultaneously.Properties of particles were analyzed.The results show that it is effective of modified reactors to prepare micronano particles by reinforced micromixing.Drug particles exhibit 100～200 nm flake crystal and remain stable microstructure.The reinforcement is adapted to anti-solvent precipitation as rapid physical process,and high gravity reactor has the highest preparation efficiency.
Keywords：liquid phase precipitationmicromixingpentoxyverine citratemicro-nano particlemodified reactor
Publication Date：2017-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 24-27,31 )