Preparation and characterization of pentoxyverine citrate coated lactose powders
CHEN Bo
HUANG Yongpeng
JIAO Jianlan
ZHONG Hui
ZOU Chuanpin
Abstract：Hi gh drug loading inhalable pentoxyverine citrate coated lactose composite powders were prepared by high pressure homogenization-spray drying process,and their micro scopical morphology,aerodynamic property,inhalation and deposition property were characterized.The results show that the micro scopical morphology of composite powders are 0.5～2 μm spherical particles,and the drug loading rate is as much as 78.9％.Angle of repose is 29 degrees,mass median aerodynamic diameter is 0.99 μm,aerosol availability is 63.2％,and fine particle fraction is 19.3％.All above properties of composite powders are effective for drug delivery of dry powder inhalers.
Keywords：pentoxyverine citratelactosespray dryinghigh pressure homogenization
Publication Date：2017-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：4( 64-67 )