Analysis of Current Status of Uric Acid in the Population Aged 18 to 60 Undergoing Physical Examinations and Its Correlation with Renal Function in A Certain Hospital of Zhengzhou
Fang Xin
Zhao Huizhen
Chen Yanyan
Yan Qiaohui
Liu Qing
Wang He
Abstract：OBJECTIVE To analyze the current status of hyperuricemia(HUA)among individuals aged 18 to 60 undergoing health check-ups and its correlation with kidney function in a certain hospital.METHODS A total of 33 112 individuals aged 18 to 60 who had health check-ups at Zhengzhou Central Hospital from 2021 to 2023 were selected.General information and laboratory data were collected.The distribution status of HUA was analyzed to identify factors affecting HUA and its correlation.RESULTS The prevalence of HUA among the health check-up population aged 18 to 60 was 21.93％,with a trend of younger men(x2=367.40,P＜0.01);the prevalence across all age groups was higher in men than in women(P＜0.01).Logistic regression indicated that eGFR,body mass index(BMI),diastolic blood pressure(DBP),blood urea nitrogen(BUN),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),and glycated hemoglobin(HbA1c)were influencing factors for HUA(P＜0.05).Grouping by eGFR＜90 ml·min-1·(1.73 m2)-1 and eGFR≥90 mL·min-1·(1.73 m2)-1 showed that there was a difference in HUA prevalence between the two groups(x2=422.847,P＜0.01);after adjusting for confounding factors,the risk of eGFR＜90 mL·min-1·(1.73 m2)-1 in the HUA group was 2.11 times that of the normal uric acid group(95％CI:1.936～2.299,P＜0.01).CONCLUSION Among individuals aged 18 to 60 undergoing health check-ups in a certain hospital of Zhengzhou,there is a trend of younger males experiencing HUA,with a prevalence higher than that of females;abnormalities in eGFR,BMI,DBP,BUN,TG,HDL-C,LDL-C,FBG,and HbA1c all increase the risk of HUA;HUA is an independent risk factor for abnormal kidney function.
Keywords：physical examination populationhyperuricemiarenal functioncorrelation
Publication Date：2025-11-10
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )