A Cross-Sectional Study of Sleep Duration and Risk of Stroke in the Middle-Aged and Elderly Population
Yi Yangyang
Ma Xing
Ma Kun
Abstract：OBJECTIVE To quantify the strength of association between sleep duration and stroke risk,and to elucidate the moderating effects of gender,urban-rural setting,and chronic diseases,thereby informing the formulation and refinement of public health policies.METHODS Utilising data from the China Health and Retirement Longitudinal Study,it included 19 350 middle-aged and older adults aged 45 years and above.A multi-model stratified analysis was employed to examine the association between sleep duration and stroke risk,along with its potential mechanisms.RESULTS Abnormal sleep duration(either insufficient or excessive)constitutes a significant modifiable risk factor for cardiovascular and cerebrovascular diseases.Both insufficient sleep time(＜6 hours)and excessive sleep time(＞8 hours)substantially elevate stroke risk,with the association exhibiting marked heterogeneity across gender,residential location,and chronic disease subgroups.CONCLUSION Both insufficient sleep time(＜6 hours)and excessive sleep time(＞8 hours)substantially elevate stroke risk among middle-aged and elderly Chinese individuals.Risk heterogeneity is pronounced,with males,rural residents,and those with chronic diseases constituting stroke high-risk groups.Potential biological mechanisms include metabolic dysregulation,inflammatory activation,and blood pressure fluctuations.Tailored interventions addressing population-specific characteristics are warranted to mitigate stroke risk in this demographic.
Keywords：strokesleep durationmiddle-aged and older adultsriskcross-sectional study
Publication Date：2025-11-10
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：5( 14-18 )