Risk Association of Genetic Factors with the Development of Diabetic Kidney Disease:A Cross-Sectional Study Based on Polymorphisms in the LXR Gene

Lan Xushan; Wu Chenguang; Liu Peng

doi:10.3969/j.issn.1001-568X.2025.10.0028

Abstract：OBJECTIVE To investigate the association between LXR gene polymorphisms(rs3758673 and rs12221497)and diabetic nephropathy risk through genetic analysis.METHODS A total of 209 patients with type 2 diabetes and 209 diabetic nephropathy patients were enrolled from October 2022 to November 2024 at Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital.TaqMan SNP genotyping was used for genetic polymorphism analysis,and logistic regression models were employed to examine the relationship between LXR rs3758673 and rs12221497 polymorphisms and diabetic nephropathy susceptibility.RESULTS Three genetic models(additive,dominant,and recessive)were applied to evaluate the genotype associations between LXR rs3758673 and rs12221497 polymorphisms and diabetic nephropathy.Logistic regression analysis revealed that in the additive model of LXR rs3758673,patients with CT genotype(OR=0.319,95%CI:0.066～0.294,P＜0.05)and TT genotype(OR=0.283,95%CI:0.136～0.590,P＜0.05)showed significantly elevated risks of diabetic nephropathy when using CC genotype as the reference.In the dominant model,CT+TT genotype(OR=0.363,95%CI:0.228～0.578,P＜0.05)demonstrated increased risk when CC genotype was the reference.The recessive model revealed that TT genotype(OR=0.203,95%CI:0.101～0.406,P＜0.05)significantly increased diabetic nephropathy risk when CC+CT genotype served as the reference.Notably,no association was observed between these genotypes and diabetic nephropathy occurrence in additive,dominant,or recessive models for LXR rs12221497.CONCLUSION While all genotypes at LXR rs3758673 showed associations with diabetic nephropathy occurrence in additive,dominant,and recessive models,none of the genotypes at rs 122214973 exhibited such correlations in these models.