Meta-Analysis of Antiviral Therapy Combined with HBIG to Block Mother-to-Child Transmission of HBV in Pregnant Women with High Viral Load
Ti Huihui
Ma Zhijie
Abstract：OBJECTIVE To comprehensively evaluate the effect of antiviral treatment combined with children's hepatitis B immunoglobulin injection on blocking mother to child transmission of hepatitis B virus in pregnant women with high viral load,and to provide scientific basis for targeted comprehensive intervention measures to block mother to child transmission of key populations.METHODS CNKI,CBM,Wanfang,VIP,PubMed databases were searched to collect and compare the randomized controlled trials of antiviral therapy combined with HBIG and simple HBIG to block the mother to child transmission of HBV high viral load pregnant women from 2015 to 2024.The blocking rate of mother to child transmission of hepatitis B in newborns in the combined intervention and simple intervention groups was selected as the effect amount,and the stata software was used for meta analysis.RESULTS A total of 10 studies that met the criteria were included,with a total sample size of 2 746 cases.The results showed that the mother to child transmission blocking rate in the combined intervention group was higher than that in the simple intervention group(OR=7.32,P＜0.05).CONCLUSION The maternal and infant blocking effect of antiviral therapy combined with HBIG in pregnant women is better than that of HBIG alone.
Keywords：pregnant womenhepatitis B virusvirus DNA loadblocking of mother-to-child transmissionmetaanalysis
Publication Date：2025-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 36-38 )