Safety Analysis of Replacing Measles Rubella Combined Attenuated Live Vaccine with Measles,Mumps and Rubella Combined Attenuated Live Vaccine among Children 8 Months of Age in Jiangning from 2016 to 2023
Wang Yijun
Han Mei
Tao Tao
Li Mengqi
Feng Jingyu
Abstract：OBJECTIVE To analyze the safety of replacing measles rubella(MR)combined attenuated live vaccine with measles,mumps and rubella(MMR)combined attenuated live vaccine among 8-month-old children in Jiangning District since 2019.METHODS It obtained MR and MMR doses administered data and adverse reaction data in age-eligible children during 2016-2023 from the Jiangsu Vaccination Integrated Service Management Information System and the China Immunization Program Information System,and conducted a descriptive analysis of reported adverse events following immunization(AEFI)rates among children 8～17 months of age.RESULTS The incidence of reported adverse events following MR administration was 106.20/105 in Jiangning District from 2016 to 2023.And the incidence of reported adverse events following MMR administration was 492.32/105.The reported incidence of MMR was higher than that of MR(χ2=220.571,P＜0.01).Among the clinical symptoms of general reactions,transient fever was the most common one.The most frequently reported abnormal reaction to MR vaccination was urticaria,no reports of thrombocytopenic purpura.The most frequently reported abnormal reaction to MMR was allergic skin rash,higher than that of MR(χ2=9.2571,P＜0.05).CONCLUSION Regardless of whether it was MR or MMR vaccination,the majority of AEFI are general reactions,followed by non-serious abnormal reactions.The incidence of MMR adverse reactions among children is within the expected range.
Keywords：measlesmumps and rubella combined attenuated live vaccinemeasles rubella combined attenuated live vaccineadverse events following immunization
Publication Date：2025-01-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 74-76 )