Analysis on the Detection Results and Epidemiological Characteristics of Suspected Varicella Cases of Binzhou from 2019 to 2023

Zhao Nana; Huang Ying; Sun Xiaoxiao; Sun Da; Zhang Lifang

doi:10.3969/j.issn.1001-568X.2024.09.0016

Abstract：OBJECTIVE Through the detection of varicella-zoster virus IgM antibody in the sera of suspected varicella cases from 2019 to 2023 in Binzhou of Shandong,analysis of the detection data,the incidence of varicella in Binzhou was understood,the reference was provided for relevant departments to formulate varicella prevention and control strategies.METHODS The serum samples from suspected cases of varicella in Binzhou were collected from 2019 to 2023,and their IgM antibodies were detected by enzym-linked immunosorbent assay(ELISA),and the distribution characteristics of population,region,time and vaccination were analyzed.RESULTS From 2019 to 2023,a total of 802 serum samples were collected in Binzhou,and 441 samples were positive,with a positive rate of 54.99%.The cases were mainly concentrated in the age of 20 and below,accounting for 80.04%of the positive component.There was no significant difference in the positive rate of antibody between male and female(P＞0.05).The onset of varicella was seasonal,with peaks in May and October.The positive detection rate of cases with no history of varicella vaccination was higher than that of those with history of vaccination,and the difference was statistically significant(χ2=20.329,P＜0.05).CONCLUSION From 2019 to 2023,the onset time of varicella in Binzhou showed a bimodal distribution,the incidence of the disease was mainly students,and the age of onset shifted backward.It is suggested that relevant departments should strengthen publicity efforts,strengthen daily surveillance in schools,incorporate varicella vaccine into the national immunization program as soon as possible,and increase the vaccination rate of varicella vaccine,so as to effectively prevent and control the spread of varicella.