Clinicopathological and molecular genetic characteristics and recurrence risk of atypical meningioma
JIANG Tao
ZHAO Jing
XIONG Danting
ZHANG Zihe
CHEN Si
GAN Wenjuan
Abstract：Objective To investigate the clinicopathological and molecular genetic features of atypical meningioma and its recurrence risk.Methods A total of 10 cases of atypical meningioma were collected from the Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital)from 2021 to 2023.The molecular genetic characteristics were detected by second-generation sequencing,and the factors related to recurrence risk were analyzed by histopathology and molecular genetic characteristics.Results Among the 10 cases of atypical meningiomas,there were 5 cases of brain tissue invasion,5 cases of high mitotic figures(4-19/10HPF),8 cases of increased cell density,7 cases of lamellar structure,4 cases of obvious nucleolus,3 cases of high nucleo-plasma ratio,and 2 cases of spontaneous necrosis.Second-generation sequencing detected 1 case of homozygous CDKN2A/B deletion and 1 case of heterozygous deletion,8 cases of 22q deletion,6 cases of 1p deletion,4 cases of 10p/q deletion,4 cases of 18p/q deletion,3 cases of 6q and 14p/q deletion,2 cases of 3p,4p/q deletion and 17q amplification,and 1 case of 19q deletion,5p/q amplification and 20q amplification.NF2 mutation was detected in 7 cases,ARID1A mutation in 2 cases,TRAF7,AKT1,KDM6A mutation in 1 case each.Co-deletion of chromosomes 1p and 22q or deletion of chromosome 10p/q or 18p/q were statistically associated with recurrence in atypical meningioma.There was a significant difference between the grade of integrated grading and recurrence(P<0.05).Conclusion Atypical meningioma has many molecular genetic changes.Co-deletion of chromosomes 1p and 22q or deletion of chromosome 10p/q or 18p/q in atypical meningioma may indicate a higher risk of recurrence.The integrated grade may be better than the histological grade in evaluating the recurrence risk of atypical meningiomas.
Keywords：atypical meningiomamolecular geneticsWHO classificationintegrated classificationrecurrence risk
Publication Date：2026-01-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：7( 84-90 )