Pure large cell neuroendocrine carcinoma of the ovary:a clinicopathological study and review of literature
WANG Xiuzhen
BA Sheng
GOU Tao
LUO Jinjiao
Abstract：Objective To investigate the clinicopathological characteristics,diagnosis,and differential diagnosis of pure large cell neuroendocrine carcinoma(PLCNEC)of the ovary.Methods Clinical and pathological data of a patient with PLCNEC of the ovary was collected,and relevant literature was reviewed.Results The patient was a 69-year-old female.Pelvic exploration revealed numerous cancer nodules throughout abdominal wall,severe adhesion between the uterine adnexa and intestinal tract,and an enlarged right ovary.Biopsy was performed on part of the ovarian tissue and metastatic lesions.Microscopically,the tumor cells were arranged irregularly in solid or sheet-like patterns,with extensive necrosis in the center and surrounding areas.The tumor cells were large in size,round or irregular,with eosinophilic cytoplasm,large and hyperchromatic nuclei,and mitotic figures were easily visible.Immunohistochemically,the tumor cells were diffusely positive for AE1/AE3,CD56,CgA,SYN,and INSM1,with a high Ki67 index.Conclusion PLCNEC of the ovary is extremely rare and prone to clinical misdiagnosis.It should be differentiated from common epithelial-derived malignant tumors of the ovary.Diagnosis requires comprehensive analyses of clinical data,microscopic morphology,and immunohistochemical results.Treatment primarily involves surgery combined with chemotherapy,and the prognosis is poor..
Keywords：Large cell neuroendocrine carcinomaOvaryPathological diagnosisImmunohistochemistry
Publication Date：2026-01-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )