Uterine adenosarcoma with heterologous stromal differentiation:a clinicopathological analysis and review of literature
HUANG Xiangning
ZHANG Han
CHENG Zhiqiang
QI Jingwen
Abstract：Objective To investigate the clinicopathological characteristics,diagnostic criteria,and therapeutic strategies for uterine adenosarcoma.Methods Clinicopathological data from two cases of uterine adenosarcoma confirmed by hematoxylin-eosin(HE)staining and immunohistochemistry were retrospectively analyzed,supplemented by a comprehensive literature review.Results Histologically,the tumors exhibited a biphasic architecture comprising benign endometrial-like glands and sarcomatous spindle stromal cells arranged in fascicles or whorls.A distinctive"cuff-like"stromal condensation surrounding the glands was observed.One case demonstrated heterologous differentiation with chondrosarcomatous and rhabdomyosarcomatous components.Immunohistochemical analysis revealed positive expression of CD10,ER,and PR in stromal cells,while heterologous areas showed S-100 positivity,indicating chondrosarcomatous differentiation and myogenin/MyoD1 expression,suggesting rhabdomyosarcomatous differentiation.Epithelial markers(CK),myogenic markers(desmin,SMA),and P53 were uniformly negative.Conclusion Uterine adenosarcoma is a rare biphasic neoplasm characterized by benign glandular epithelium and sarcomatous stromal components.It lacks distinctive clinical manifestations,laboratory findings,or imaging features,and definitive diagnosis relies on the histomorphological characteristics and immunohistochemical analysis.
Keywords：adenosarcomauterine neoplasmshistopathological diagnosisheterologous differentiationdifferential diagnosis
Publication Date：2026-01-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 51-54,110 )