Features of testicular spermatocytic tumor:a clinicopathologic analysis and review of literature
GAO Ya
HE Huihua
YAN Honglin
YUAN Jingping
KE Xiaokang
Abstract：Objective To investigate the clinicopathological features,diagnosis,and differential diagnosis of spermatocytic tumor of the testis.Methods A retrospective analysis was conducted on the clinicopathological data of two cases of spermatocytic tumor diagnosed and treated at Renmin Hospital of Wuhan University between December 2024 and March 2025,along with a review of relevant literature.Results Both patients were middle-aged to elderly males.Case 1 was admitted due to swelling of the right scrotum for over one year,while Case 2 presented with right testicular pain for 10 days.Neither had a history of cryptorchidism.Microscopically,the tumors were relatively well-circumscribed,exhibiting solid nodular or nested growth patterns.The stroma showed delicate fibrous septa,hemorrhage,and edema,with focal pseudoglandular or trabecular structures.The tumor cells consisted of small,medium,and large cell types,with no evidence of germ cell neoplasia in situ(GCNIS)in the surrounding seminiferous tubules.Immunohistochemically,both cases demonstrated variable positivity for SALL4 and CD117,with a Ki-67 proliferation index of approximately 40%.All other immunomarkers were negative.Conclusion Spermatocytic tumor of the testis is a rare germ cell neoplasm unrelated to GCNIS.Its typical histological feature is the presence of three distinct cell types(small,medium,and large),with possible anaplastic or sarcomatoid changes.Radical orchiectomy remains the primary treatment for this tumor.
Keywords：Spermatocytic tumorTestisClinicopathological analysis
Publication Date：2026-01-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：4( 47-50 )