Clinicopathological characteristics of mixed neuroendocrine-non-neuroendocrine neoplasms of cervix:an analysis of 14 cases

QIAO Qi; YUE Yamin; YU Ning

doi:10.3969/j.issn.1007-8096.2026.01.003

Abstract：Objective To analyze the clinical features,pathological characteristics,treatment modalities,and prognosis of 14 cases of mixed neuroendocrine-non-neuroendocrine tumors of the cervix,with review of the relevant literature to deepen the cognition of these tumors.Methods We retrospectively analyzed and summarized the clinical data,microscopic morphological features,immunohistochemical phenotypes,treatment,and prognosis of 14 cases of mixed neuroendocrine-non-neuroendocrine tumors of the cervix from 2014 to 2024 at the Affiliated Hospital of Binzhou Medical University.The clinicopathological features,treatment methods,and prognosis-related factors of these tumors were investigated.Results The age of patients ranged from 29 to 72 years,with an average age of 49.5 years.According to the International Federation of Gynecology(FIGO)clinical stage,1 case was in stage IA1,2 cases were in stage IB1,5 cases in stage IB2,1 case in stage II A,1 case in stage IIB,1 case in stage Ⅲ,and 3 cases in stage IV.The neuroendocrine component was most commonly small cell carcinoma(SCNEC)(9/14),while the non-neuroendocrine component was the most common type of adenocarcinoma(5/14).Immunohistochemical staining showed neuroendocrine markers of Syn,CgA,and CD56 were positive in 92.8%(13/14),71.4%(10/14),and 78.6%(11/14)of cases,respectively.Ki-67 proliferation index was 60%～90%.The results of HPV detection were positive in 14 cases,and 9 cases were HPV18 positive.13 patients were followed up for 6 to 119 months,of which 3 died,and 3 cases were found to have metastasis.Conclusion Mixed neuroendocrine-non-neuroendocrine tumors of cervix are rare malignant tumors with a poor prognosis.Diagnosis needs to be combined with histological morphology and immunohistochemical markers.