Ovarian clear cell carcinoma:a clinicopathological analysis of 39 cases
ZHANG Xueping
WANG Xuan
XIA Qiuyuan
LI Xueqin
XIA Chun
RAO Qiu
Abstract：Objective To investigate the clinicopathological features of ovarian clear cell carcinoma(OCCC)in order to provide evidence for its diagnosis and treatment.Methods Thirty-nine cases of OCCC were collected for analysis of their histopathological and immunohistochemical features.Follow-up was conducted until April 2025.Results The average age of the patients was 52 years,and among them,66.7%of cases were classified as early-stage FIGO(26/39,including 20 Stage I and 6 Stage II).Five patients died within one year after surgery,five were lost to follow-up,and 29 cases remained disease-free.Among four patients with p53 mutations,two experienced one recurrence and one had twice recurrences;all were disease-free at the end of follow-up.Most tumors were unilateral(76.9%),with solid-cystic or solid cut surfaces and an average diameter of 9 cm.Microscopically,the tumors exhibited various patterns,including cystic-tubular,sieve-like,papillary,and solid structures,with 69.2%showing eosinophilic secretions.Tumor cells were diverse in morphology,with clear or eosinophilic cytoplasm and varying nuclear grades.Immunohistochemistry showed high expression of Pax-8,HNF-1β,and Napsin A,and low expression of WT-1.The mutation rate of p53 was 10.26%,and the loss rate of ARID1α expression was 25.81%.Conclusion OCCC is characterized by unique clinicopathological and molecular features.The combined application of HNF-1β and Napsin A serves as important immunohistochemical markers for OCCC diagnosis.Loss of ARID1α expression and p53 mutation status are significant for individualized therapy.
Keywords：Ovarian clear cell carcinomaImmunohistochemistryMolecular characteristicsDifferential diagnosis
Publication Date：2026-01-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 5-9 )