Expression of DLGAP5 and HMMR in lung cancer tissues and their clinicopathological significance
ZHANG Guangjun
YAO Chunmei
HUI Hong
WANG Mina
SU Lei
Abstract：Objective To explore the expression of Discs large homologous affinity protein 5(DLGAP5)and hyaluronan-mediated motility receptor(HMMR)in lung cancer tissues and their relationship with clinical pathological characteristics and prognosis,in order to enhance the understanding of this disease.Methods A total of 80 patients with advanced lung cancer who were admitted to the hospital from April 2022 to April 2024 and scheduled to receive sintilimab combined with chemotherapy were prospectively enrolled as study subjects.Minimally invasive biopsy were used to collect samples of cancer tissues and adjacent normal tissues.Immunohistochemistry was employed to detect the differential expression of DLGAP5 and HMMR between cancer tissues and adjacent normal tissues,and the relationships between their expression and the clinical pathological characteristics and prognosis of patients were analyzed.Results The proportion of high expression of DLGAP5 and HMMR in cancer tissues was significantly higher than that in adjacent normal tissues(P＜0.05);Significant differences were observed in the expression of DLGAP5 and HMMR in cancer tissues among different TNM clinical stages and differentiation degrees(P＜0.05).Spearman rank correlation analysis showed that the expression of DLGAP5 and HMMR in cancer tissues was significantly correlated with TNM clinical staging and differentiation degree(P＜0.05).High expression of DLGAP5 and HMMR was associated with a poorer prognosis.The proportions of patients with TNM clinical stage IV,poor differentiation,high expression of DLGAP5,and high expression of HMMR in the death group were significantly higher than those in the survival group(P＜0.05).Univariate Cox regression analysis showed that TNM clinical stage,differentiation degree,DLGAP5 expression,and HMMR expression were related to patient prognosis.Multivariate analysis further confirmed that TNM clinical stage,differentiation degree,DLGAP5,and HMMR were independent prognostic factors affecting patient outcomes(P＜0.05).Conclusion DLGAP5 and HMMR are highly expressed in cancer tissues of lung cancer patients and are associated with prognosis,suggesting that DLGAP5 and HMMR may become potential molecular targets for the treatment of lung cancer.
Keywords：Discs large homologous affinity protein 5Hyaluronan-mediated motility receptorNon-small cell lung cancerSintilimabClinicopathology
Publication Date：2025-12-28
Online Publishing Date：2026-01-28(First online date of this platform, not the publication date of the document)
Pages：6( 1650-1655 )