Screening for cervical lesions via ThinPrep cytologic test combined with HPV testing:data from 9,867 cases in Baoding area

LI Li; LIU Jiaqi; WU Rui; ZANG Peng; WEN Shi

doi:10.3969/j.issn.1007-8096.2025.12.019

Abstract：Objective To investigate the epidemiological characteristics of cervical cancer and precancerous lesions among women in Baoding area,and to explore the clinical significance of combined ThinPrep cytologic test(TCT)and human papillomavirus(HPV)genotyping in screening for cervical cancer and precancerous lesions.Methods A total of 9,867 women who were screened for cervical lesions at the Gynecology Clinic of Maternal and Child Health Hospital of Baoding City were selected.All patients underwent both TCT and HPV genotyping testing.The patients with positive results of TCT and/or HPV genotyping were subject to colposcopy and histopathological examination,with histopathological results as the diagnostic criteria.The diagnostic values of TCT alone,HPV genotyping alone,and their combination in screening for cervical cancer and precancerous lesions were compared and analyzed.Results Among the 9,867 subjects,the number of positive cases for TCT and HPV genotyping was 741(7.5%)and 1,771(17.9%),respectively.A total of 717 cases with positive TCT and/or HPV genotyping underwent colposcopy and histopathological examination.among whom 602 cases(83.96%)were histopathologically positive.Specifically,there were 455 cases(63.46%)of low-grade squamous intraepithelial lesion(LSIL/CINⅠ),130 cases(18.13%)of high-grade squamous intraepithelial lesion(HSIL/CIN Ⅱ-Ⅲ),13 cases(1.81%)of cervical squamous cell carcinoma,and 4 cases(0.56%)of cervical adenocarcinoma.With histopathological results as the diagnostic criteria,the number of cervical cancer and precancerous lesions detected by TCT alone,HPV genotyping alone,and their combination was 401,565,and 602 cases,accounting for 55.93%(401/717),78.80%(565/717),and 83.96%(602/717)among the total screened cases,respectively.The histopathological positivity rate of TCT and HPV genotyping combined screening was significantly higher than that of TCT alone or HPV typing alone,with a statistically significant difference(P<0.05).Conclusion Combined screening with TCT and HPV genotyping can improve the detection rate of cervical cancer and precancerous lesions,reduce missed diagnoses,and is a relatively accurate and reliable screening method.