Metastatic clear cell carcinoma of the ovary misdiagnosed as lung adenocarcinoma:report of a case
XIE Lingping
DU Tianhai
JIANG Dan
Abstract：Objective: To explore the clinical pathological features and immunohistochemical phenotype of metastatic ovarian clear cell carcinoma (OCCC). Methods: A rare case of ovarian clear cell carcinoma metastasizing to the lung was reported, and its clinical data, histological characteristics, and immunohistochemistry were analyzed and discussed. Results: A 48-year-old female patient presented with cough and sputum, and chest CT showed a mass in the lower lobe of the right lung, measuring 4.7 cm × 3.8 cm × 2.8 cm. The cut surface was gray-white or gray-brown, solid, and medium in consistency. Microscopically, the tumor showed papillary and lepidic growth patterns, with polygonal tumor cells exhibiting a 'shoe钉-like' appearance, large nuclei, marked anaplasia, and eosinophilic or clear cytoplasm. Immunohistochemistry showed positivity for HNF-1β, NapsinA, PAX8, and CK7, and negativity for TTF-1. Based on the patient's medical history, the diagnosis was ovarian clear cell carcinoma with pulmonary metastasis. Conclusion: Metastatic ovarian clear cell carcinoma to the lung is rare. Its histological morphology can be easily misdiagnosed as primary pulmonary adenocarcinoma. A definitive diagnosis requires careful consideration of the patient's clinical history and immunohistochemical staining. Pathologists should maintain high vigilance when diagnosing metastatic tumors to avoid misdiagnosis.
Keywords：Ovarian clear cell carcinomaPulmonary metastasisOvarian cancerClinical pathology
Publication Date：2025-11-28
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：3( 1524-1526 )