Research progress on tumor budding in colorectal cancer
WU Jingbo
LIU Xiuping
Abstract：Colorectal cancer(CRC)is one of the malignant tumors with high morbidity and mortality worldwide.In recent years,tumor budding,as an important biological feature of CRC,has gradually received attention from researchers.Tumor budding not only affects the invasiveness and metastatic ability of the tumor,but also is closely related to the prognosis of patients.Despite the current progress in the study of tumor budding,its specific biological mechanisms and complex interactions with the tumor microenvironment still need to be explored in depth.In this paper,we review the latest research progress of CRC tumor budding,including its biological mechanism,clinical significance,application of new emerging technologies in tumor budding,and future research directions,aiming to provide new ideas and methods to improve the prognosis of CRC patients and enhance their survival rate.
Keywords：Colorectal cancerTumor buddingResearch progress
Publication Date：2025-11-28
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：6( 1505-1510 )