Histological and cytological features of mesothelioma in situ:report of one case and review of literature
LAI Lizhong
HUANG Yuxin
XU Zhiyu
LUN Jiaxin
TANG Ying
LIU Dong
Abstract：Objective To explore the morphological characteristics of mesothelioma in situ(MIS)and to improve the morphological understanding of such lesions.Methods Clinical data of one MIS patient were collected,and the morphological features were retrospectively analyzed by effusion cytology,tissue biopsy,immunohistochemical staining and FISH detection,and the literature was reviewed.Results Significant morphological differences were observed between histological biopsy and hydropleural cytology.The histological morphology appeared benign and mild with consistent cell size,while the cytological morphology showed marked atypia,with large and hyperchromatic nuclei.By immunohistochemistry,they all showed positive expression of D2-40,CK5/6,Calretinin and CK,negative expression of TTF-1,and some weak expression of BAP-1.Both CDKN2A/P16 FISH assays were homozygous deletions.Based on the clinical presentation,imaging findings,and thoracoscopic examination results,the diagnosis was consistent with MIS.Conclusion MIS can exhibit morphological differences between serous effusions and tissue biopsy and the diagnosis should be comprehensively evaluated by combination with the clinical presentation,pathological morphology,immunohistochemistry,and related genetic testing results.
Keywords：Mesothelioma in situHydropleural cytologyPathological morphological featuresCDKN2A/P16
Publication Date：2025-11-28
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：4( 1501-1504 )