Clinicopathological features of primary SMARCA4-deficient sinonasal carcinoma
FAN Ruirui
Abstract：Objective To summarize the clinical and pathological features of primary SMARCA4-deficient nasal and paranasal sinus carcinoma. Methods Clinical data of a patient with primary SMARCA4-deficient nasal and paranasal sinus carcinoma were collected. The clinical and pathological characteristics were analyzed by H&E staining, immunohistochemistry, and molecular testing. Results Under low magnification: tumor cells infiltrated within the mucosa and submucosa, arranged in nests and diffuse solid sheets, with necrosis, no glandular, squamous, or other differentiation features. Under high magnification: the tumor showed a syncytial-like appearance, with high nuclear-to-cytoplasmic ratio and prominent nucleoli. Immunohistochemical results: tumor cells expressed CKpan, CAM5.2, Syn, and INI-1, but not BRG1, P63, NUT, Desmin, LCA, or S100. Molecular testing: ERER(-). Conclusion Primary SMARCA4-deficient nasal and paranasal sinus carcinoma is rare, with non-specific pathological morphology, which is easily misdiagnosed. Timely and accurate diagnosis has important guiding significance for the treatment and prognosis of patients.
Keywords：Nasal and paranasal sinusesSMARCA4CarcinomaHistopathologyDiagnosis and differential diagnosis
Publication Date：2025-11-28
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：3( 1495-1497 )